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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract: virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serumThe production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBVTherefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBVTherefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuationThe clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: with chronic renal failure, whether they have had hemodialysis or not, the specificity of some of the serumThe effects of renal function and hemodialysis were examined on serum levels of some of the tumor markersThere were no significant differences among the three groups in the serum concentrations of CA, AFP,of the corresponding tumors was decreased while serum AFP, CA, CA, PSA and fPSA were as valuable asHemodialysis further increased the serum level of CA and NSE.

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: Direct acting antiviral (DAA) treatments may reduce the elevated α fetoprotein (AFP), but data on how these treatments affect elevated AFP in patients with chronic hepatitis C (CHC) remain insufficient. In the present study, the frequency of baseline AFP elevations and their related factors, AFP dynamics during and after DAA treatment, and factors associated with AFP reduction was assessed. This retrospective study included 141 patients with CHC without hepatocellular carcinoma who received DAA and achieved sustained virological response. The details are as follows: mean post-treatment follow-up was 99 weeks (12–213); mean age, 57.8 years old; 52%, males; 79%, genotype (GT) 1; and 47%, cirrhosis. Pre-treatment AFP elevation (>5.5 ng/mL) was seen in 48.2% patients. On multivariate analysis, baseline AFP>5.5 was associated with the presence of cirrhosis ( =0.001), co-existing non-alcoholic steatohepatitis (NASH) ( = 0.035), and GT 1 ( = 0.029). AFP normalization was seen in 28.2% patients at treatment week 2, in 52% at the end of treatment, and in 73.4% at the end of follow-up. Post-treatment week 24 AFP normalization was associated with the absence of cirrhosis ( = 0.003), Child–Pugh score<6 ( = 0.015), and baseline AFP<10 ( = 0.015). AFP elevation is common in patients with CHC and independently associated with NASH, cirrhosis, and GT 1. DAA treatment resulted in AFP normalization as early as treatment week 2. Post-treatment week 24 AFP normalization is independently associated with the absence of cirrhosis, Child–Pugh score<6, and baseline AFP<10.

Keywords： chronic hepatitis C     α fetoprotein     direct acting antiviral treatment     cirrhosis    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: Therefore, identifying serum biomarkers that indicate MPP progression and exploring new targeted drugsIn this study, serum samples were collected from patients with general MPP (GMPP) and SMPP to conduct

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein     mechanistic target of rapamycin kinase inhibitor    

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The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 352-355 doi: 10.1007/s11684-007-0067-6

Abstract: The aim of this paper was to investigate the change of serum leptin and its relationship with plateletSerum leptin was detected by enzyme linked immunosorbent assay.Multifactorial stepwise regression analysis showed that serum leptin in CHD patients was independentlyLogistic analysis demonstrated that serum leptin was independently correlated with the risk of CHD (serum leptin could affect blood platelet activation.
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Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0907-9

Abstract: The effects of PES membrane interfacial electrokinetic property on the bovine serum albumin (BSA) membrane

Keywords： Charged PES UF membrane     BSA     Electrokinetic characterization     Adhesion force     Jump distance    

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Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 5-10 doi: 10.1007/s11684-008-0002-5

Abstract: We assessed the secular trends in the serum lipid levels in Shanghai residents from 1973 to 1999.from four independent, cross-sectional, population-based surveys were used to analyze the trends in serumSerum lipid levels were measured in a single laboratory throughout the entire study period.A non-significant increase was noted from 1973–1974 to 1982–1983 in the serum lipid profiles; howeverSimilar trends were observed in the mean serum triglyceride (TG) and the mean serum low-density lipoprotein
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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 101-105 doi: 10.1007/s11684-011-0111-4

Abstract: The serum TNF-α level was detected using radioactive immunity.The results showed that β-elemene can downregulate the levels of plasma endotoxins, serum TNF-&alpha

Keywords： liver fibrosis     beta-elemene     endotoxin     CD14    

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Mechanism of hepatocellular damage in rat caused by low serum selenium

LU Yi, QU Bo, LIU Chang, YU Liang, Liu Xuemin, WANG Haohua, JIANG An, ZHANG Xiaogang

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 255-258 doi: 10.1007/s11684-008-0048-4

Abstract: The aim of this paper is to investigate the mechanism of hepatocellular damage in rats caused by low serumAt the end of the 12 week, the levels of serum selenium, glutathione peroxidase (GPX) and malondialdehydeThe levels of serum selenium and GPX in group A were markedly lower than those in group B.

Keywords： process     glutathione peroxidase     hepatocellular damage     group     Keshan Disease    

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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 235-240 doi: 10.1007/s11684-010-0002-0

Abstract: This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durationsMaternal serum levels of TXB2 were measured by enzyme-linked immunoassay.till the end of pregnancy (control group). (2) With development of pregnancy, the levels of maternal serumHigher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared.The maternal serum TXB2 after 20 weeks of gestation had predictive value, and the index after 30 weeks

Keywords： thromboxane B2     preeclampsia    

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serumWe identified tRF-Gln-TTG-006, which was remarkably upregulated in HCC serum (training cohort: 24 HCCIn summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA     biomarker     hepatocarcinoma    

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Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 457-462 doi: 10.1007/s11684-010-0240-1

Abstract: This study was performed to determine the prognostic role of preoperative serum carbohydrate antigenThe association between serum CA19-9 level and lymph node involvement was also assessed.

Keywords： cholangiocarcinoma     prognostic factors     serum carbohydrate antigen 19-9    

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The effect of HCG-day serum progesterone and estradiol concentrations on pregnancy outcomes in IVF/ICSI-ET

Zhou Danni,Yang Jing,Wu Gengxiang,Li Saijiao,Yu Nan,Zhao Meng and Wen Yanqi

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 79-84

Abstract:

To evaluate the effect of serum progesterone and estradiol concentrationsAnd according to the serum progesterone value，the patients are divided into two groups，One group is thevalue of serum progestrone which is less than 2.0 pg/mL on the day of injecting HCG，the other is thevalue of serum progestrone which is equal or greater than 2.0 pg/mL on the day of injecting HCG.ThenConclusion on day of injecting HCG，serum progesterone levels can reduce clinical pregnancy rates and

Keywords： the value of serum progestrone     on day of injecting HCG     fresh IVF/ICSI cycles     clinical pregnancy rate    

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Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Review

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Engineering 2019, Volume 5, Issue 1,   Pages 60-68 doi: 10.1016/j.eng.2018.11.008

Abstract: The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative

Keywords： Chinmedomics     Serum pharmacochemistry of TCM     Efficacy     Metabolomics     Syndrome     Biomarkers     Quality markers    

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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinineUACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESRThese findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in

Keywords： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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Title Author Date Type Operation

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum

Journal Article

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Journal Article

Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

Journal Article

Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Journal Article

Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Journal Article

Mechanism of hepatocellular damage in rat caused by low serum selenium

LU Yi, QU Bo, LIU Chang, YU Liang, Liu Xuemin, WANG Haohua, JIANG An, ZHANG Xiaogang

Journal Article

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article

Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

Journal Article

The effect of HCG-day serum progesterone and estradiol concentrations on pregnancy outcomes in IVF/ICSI-ET

Zhou Danni,Yang Jing,Wu Gengxiang,Li Saijiao,Yu Nan,Zhao Meng and Wen Yanqi

Journal Article

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article